The unincorporated village of Bustamante, settled by Don Pedro Jose Bustamante and his family in 1822, is located on a 22,142-acre land grant awarded by the Mexican government to Bustamante in 1835. He brought other settlers, horses, cattle, sheep, and goats to help open up the frontier. An early sandstone blockhouse built by the Bustamante family provided protection from Indian raids. During the 1870s the village became the headquarters of Rancho Las Comitas, named for the Comita tree which grew on the property. Las Comitas gave rise to a community of homes, a school and a store, making the ranch almost self sufficient. Part of the land later was claimed by the State of Texas in a Supreme Court case.
Numerous Bustamante family members are buried in three ranch cemeteries: the Bustamante Cemetery, the Cameron Cemetery, and the Gracia Cemetery. The community was officially named Bustamante in 1926 when a post office was established with Herlinda Bustamante as postmistress. Ranch life changed in the 1930s with the discovery of oil and gas in the area. Although much of the land was leased for exploration wells, the ranch is still in operation under the direction of Bustamante descendants.