The Flores de Abrego family came to the New World from northern Spain before the time of the American Revolution. During the 18th century, members of this family brought their cattle northward and established ranches along the San Antonio River. The head of this family was Francisco Antonio Flores de Abrego II (d. 1757), who married Rosa Hermenegilda Hernandez. Their son, Jose Joaquin Flores de Abrego (1742-c. 1800), grew up on the San Bartolo Ranch in present Karnes County. Jose Joaquin's grandsons Manuel, Salvador, Nepomuceno, and Jose Maria later fought on the side of the Texians during the revolution for independence from Mexico.
In 1854 Josefa Agustina Flores de Abrego, daughter of Jose Maria Flores de Abrego, married Samuel William Barker, who became Wilson County's first sheriff in 1860. In 1867 Josefa's donation of 200 acres of land was accepted by the County Commissioners Court as the site for the new county seat. As she requested, the new town was named Floresville in honor of her ancestor, Francisco Antonio Flores de Abrego II. As prominent ranchers, with cattle brands registered in Floresville, the Flores de Abrego family played an important role in the colonization of this area.