Empresarios John McMullen and James McGloin brought irish catholic immigrant families to Texas about 1829 to form a new colony, San Patricio de Hibernia. Under the direction of the Rev. Henry Doyle, the colonists established Saint Patrick's Catholic Church about 1830. A fire in 1858 destroyed the original frame church building and all church records. The Rt. Rev. Jean Marie Odin, first Bishop of Texas, dedicated a replacement church building about 1859. Local citizens built a two and one half story building for a convent and school on the grounds of Saint Patrick's Church.
After an 1875 hurricane destroyed facilities at Indianola, nuns from the order of Sisters of Mercy relocated in San Patricio and operated Saint Joseph's convent and school from 1876 until 1884. After a 1919 hurricane completely demolished the church facilities, the congregation rebuilt in 1922. A need for a larger facility led the congregation to build a fourth structure in 1961. Through the years Saint Patrick's Catholic Church has served the community with sunday mass and the sacraments and missions given by visiting priests.